AOR Strontium Support II

Strontium is a trace mineral which concentrates in the skeletal system, where it supports the function of osteoblasts (the cells which form new bone) while reducing the differentiation and activity of osteoclasts (the cells which resorb old bone). Strontium Support II now provides the daily dose of strontium in just two capsules.

60 Vegi-Caps AOR08161
100% Vegetarian
SUPPLEMENT FACTS:
Serving Size: 1 Capsule
%DRI
Strontium (citrate) 341mg *

*Dietary Reference Intake not established.

Other ingredients: none. Capsule: hypromellose, sorbitol, silicon dioxide, water.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use
Take one to two capsules daily on an empty stomach, at least two hours before or after food, calcium or milk but ensure that daily calcium intake is adequate. Calcium, food and milk products significantly reduce strontium absorption if taken at the same sitting.

Main Applications
As reported by literature:
• Supports skeletal health.

Source
Pharmaceutical synthesis

Pregnancy / Nursing
No studies have been conducted. Best to avoid.

Cautions
Children, adolescents or pregnant/nursing women should not take this supplement. Do not take strontium if you are taking tetracycline or quinolone antibiotics. Talk to your health care practitioner before taking strontium if you have kidney disease.

Bone loss accelerates suddenly in menopausal women because the drop in estrogen levels causes an increase in the resorption (teardown) of existing bone. But resorption is only half of the story. Age-related bone loss is also caused by a decrease in the formation of new bone tissue.

Existing drugs for treating osteoporosis, as well as calcium and vitamin D supplements, work by reducing bone resorption. But they do not support the formation of new bone. These drugs and nutrients increase the mineralization
of bone, but they do not help the body to build new bone tissue. And in fact, within weeks of starting use of antiresorptive drugs like Fosamax,® the body's formation of new bone actually decreases. The resulting bone is less prone to fracture, but is not the same as youthful, healthy bone.

Strontium is a mineral found along with calcium in most foods. Research has long suggested that it may be an essential nutrient required for the normal development, structure, function, and health of the skeletal system. Clinical trials going back into the 1940s have supported this conclusion, but recent studies have provided evidence that it can offer unique nutritional support against loss of bone structure and function.

Animal studies have shown that Strontium supplements both decrease bone resorption, and increase the formation of new bone tissue.
• In animal models, Strontium (in various forms, such as chloride, carbonate, gluconate, and lactate) causes "baby" osteoblasts (bone-building cells) to multiply more quickly.
• Bone tissue cultures which are exposed to Strontium synthesize more bone matrix and new bone collagen. The same amount of calcium has no effect on these parameters.
• In bone tissue culture, Strontium reduces bone resorption at concentrations at which calcium has no effect, prevents the resorption caused by excessive parathyroid hormone, and slows the rate at which immature osteoclasts develop.
• Strontium-supplemented diets boost bone strength in experimental animals without a negative impact on bone quality, even at extremely high doses.

Human clinical trials also support Strontium's ability to both support new bone formation and prevent excessive resorption.
• The results of early clinical trials using Strontium (lactate) led researchers to speculate that Strontium increased osteoblast activity.
• Bone biopsies from a small human pilot trial revealed an astounding 172.4% increase in new bone formation activity after six months of Strontium (gluconate) supplementation.
• The bone-building activity of osteoblasts can be measured using bone-specific alkaline phosphatase, while crosslinked N-telopeptide (NTx) and C-telopeptide (CTx) mark the degradation of bone collagen by ravaging osteoclasts.

Calcium and Strontium: the Dynamic Tension
Calcium and Strontium can both play key roles in the health of your bones - if you use them properly. On the one hand, animal studies suggest that Strontium is not effective, and may even be counterproductive, if your calcium intake is not adequate. Current "official" recommendations suggest an intake of 1000 milligrams of calcium for younger adults, and 1200 milligrams for people over the age of 50. Some evidence suggests that a still higher intake (1300-1600 milligrams) of calcium is more effective for lowering fracture risk in the elderly. But remember that these numbers are your total calcium need. The more calcium you get in your diet, the less you need from supplements.

At the same time, however, it's important not to take your Strontium supplement at the same time as your calcium supplements. This is because calcium and Strontium use the same pathways for absorption in the intestinal tract, so swallowing a calcium supplement along with your Strontium can dramatically reduce absorption. So obviously, putting Strontium and calcium in the same pill is a recipe for bone health disaster, in which you don't get the benefits of either nutrient!

The best protocol - and the one used in the most recent clinical trials - is to take your Strontium either three hours after your last meal of the day, or one hour before breakfast in the morning, or both. Because studies suggest that one last dose of calcium just before retiring can help prevent excessive resorption of bone overnight, it may be best to take all of your Strontium before breakfast, leaving you free to take a calcium supplement just before you go to bed.

Like the Strontium carbonate crystals (strontianite) from which it was first isolated, Strontium's role in bone health has long been hidden in obscurity. But its strength has allowed it to endure, waiting for the day that it could emerge and reveal its power.

Strontium Support II conveniantly provides high-quality strontium at an effective dose in only two capsules.

References

1 Sips, AJAM et-al. Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility.Br. J Clin Pharmacol. 1996;41:543-549

2 Sips, AJAM.Absoption kinetics of strontium and calcium in human and experimental animal. Ph.D Thesis. University of Amsterdam. 1994

3 Skoryna, SC. Effects of oral supplementation with stable strontium. Can Med J. 1981;125:703-712

4 ATSDR.Toxicological profile for strontium. Atlanta,GA: Agency for toxic substances and disease registry US Dept of Health and Human Services. Public Health Services.2001

5 Leeuwenkamp,OR et-al. Human pharmacokinetics of orally administered strontium. Calcif. Tissue Int. 1990;47:136-140

6 Marie,PJ et-al. Effect of low doses of stable strontium on bone metabolism in rats. Mineral Electrolyte Metab. 1985;11:5-13

7 Shorr, E and Carter, AC. The value of strontium as an adjuvant to calcium in the mineralization of the skeleton in osteoporosis in man. Conference on Metabolic Interactions. Eds. EC Reifenstein Jr.,NY.NY.Pub J Macy Foundation 1950 pp144-154.

8 McCaslin FE and Janes, HM. The effect of strontium lactate in the treatment of osteoporosis. Proc. Mayo Clinic. 1959;34:329-334

9 Skoryna,SC and Fuskova, M. In: Skoryna, SC ed. Handbook of stable strontium.NY;Plenum:1985.p593-617

10 Comar,CL , Wasserman, RH and Nold, NM. Strontium-Calcium discrimination factors in the rat. Proc. Sco. Exp. Biol. Med.1950;92:859-863

11 Della Rossa et-al. Absorption and retention of ingested strontium and calcium in beagles as a function of age. Nature.1965;205:197-198

12 Skoryna, SC.Metabolic aspects of the pharmacologic uses of trace elements in human subjects with specific references to stable strontium. Trace Subst. Enviorn Health.1984;18:3-23

13 Dahl, SG et-al. Incorporation and distribution of strontium in bone. Bone.2001;28:446-453

14 Storey,E. Strontium "rickets" bone calcium and strontium changes. Austral.Ann. Med. 1961;10:213-222

15 Matsumoto, A. Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone. Arch. Toxicol. 1988;62:240-241

16 Marie,PJ et-al. Mechanisms of action and therapeutic potential of strontium in bone. Calcif. Tissue Int.2001;69:121-129.

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