Cognitex with Pregnenolone & NeuroProtection Complex

Cognitex with Pregnenolone & NeuroProtection Complex
90 softgels
Item Catalog Number: 922

Protecting brain health is vital if the pursuit of a longer life is to have any meaning. According to current wisdom, some degree of cognitive impairment is all but inevitable as we age.1-6 That is, unless steps are taken to prevent it.7-12

The ideal strategy for preserving brain function begins with preventing factors that may contribute to cognitive decline. Good nutrition—including dietary supplements— and a healthy lifestyle are key. As a first step toward ensuring brain health, keep your blood pressure and weight in check. However, there is much more that can and should be done to protect the aging brain. Nutritional support for the aging brain is of paramount importance.

A powerful blend of nutrients
Cognitex is formulated to take advantage of the latest developments and ingredients for cognitive health. The latest ingredient in the Cognitex formula is uridine-5’-monophosphate, a critical brain nutrient.

Uridine-5’-monophosphate (UMP) is a basic building block of RNA and DNA as well as of phosphatides such as phosphatidylcholine that are critical to optimal brain function and the health of neuronal cell membranes.* Naturally found in the milk of nursing mothers, UMP is essential not only for the growth and development of infant brains, but also for healthy cognitive function in aging adults.13 Dietary supplementation with UMP may increase brain acetylcholine and phosphatide levels, and enhance some cholinergic functions.14

The Cognitex formula provides other critical extracts that support healthy brain function, such as blueberry standardized with both anthocyanins and pterostilbene.*

Blueberry anthocyanins are considered one of nature’s most potent antioxidants and have demonstrated properties that extend well beyond suppressing free radicals. Pterostilbene, the other blueberry constituent, helps maintain healthy lipid and glucose levels in those already within normal range.8* Importantly, through their unique biological effects; pterostilbene and anthocyanins may help support DNA structure.9*

A crucial building block in the brain is phosphatidylserine (PS). In fact, brain tissues are especially rich in this nutrient, but aging causes a decline in the PS content of cells throughout the body, which can lead to cognitive decline.* Phosphatidylserine helps the brain use its fuel efficiently. By boosting glucose metabolism and stimulating production of acetylcholine, supplemental phosphatidylserine has been shown to improve the condition of patients experiencing age-associated memory impairment or cognitive decline.10,11* Thus, replacing this brain food is essential.

Life Extension’s Cognitex formulas contain a compound that mimics the naturally occurring PS in the brain. SharpPS GOLD® fortified with omega-3 fatty acids delivers PS to the brain to help retard the cognitive degeneration so often seen with advanced age.* These unique nutrients have been extensively studied and may be of tremendous benefit for the aging brain.12

More protection against free radicals
The brain is a highly active organ that produces high levels of free radicals. These free radicals can bombard the fatty membranes of neurons and other brain cells causing premature loss of function. Cognitex contains a number of phytonutrient-based antioxidants that work best in a lipid (fat) rich environment like the brain.

While antioxidant nutrients provide essential free radical protection, many have limited capacity once they have spared an electron to balance a free radical. Cognitex contains a novel rosemary extract that is rich in carnosic acid, which provides multi-step protection against free radicals in a process called the carnosic acid cascade.15 At each step of free radical interaction a new compound is formed, which in turn is a powerful antioxidant in itself.

Bioavailable to the brain
Nutritional support for the brain is challenging as a barrier called the blood-brain barrier keeps out toxins as well as beneficial nutrients and drugs. Cognitex contains a grape seed extract called Leucoselect® Phytosome™. By pairing proanthocyanidins from grape seed extract with phosphatides from soy lecithin in the Phytosome™, the uptake and distribution to target tissues of the grape seed polyphenols is enhanced.

Once in the brain, the grape seed polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These fats make up the outer lipid membrane of trillions of brain cells. These polyphenols also protect blood circulation and oxygen flow by improving the tone and elasticity of blood vessels.*

Molecular size matters
High levels of procyanidins from grape seed extract do not ensure an extract is going to have a beneficial effect on the brain. Polyphenols with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™ contains smaller size molecules for advanced neurological activity.

A difference you can feel
Taking dietary supplements can often be an act of faith as we often cannot feel what they are doing. Cognitex provides the patented, nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary standardized extract of ashwagandha, also known as “Indian ginseng,” and used in Ayurvedic traditional medicine for boosting brain function and alleviating mental fatigue. Advanced extraction practices allow for a highly concentrated yet balanced brain nutrient. The effects can often be felt immediately with greater alertness and focus but without jitteriness.

Sensoril® also helps modulate the stress response resulting in cortisol excretion. Stress can be very damaging to the brain, especially memory function, and cortisol stimulates the body to release sugar (glucose) into the bloodstream.

Advanced inflammation protection
Cognitex provides a NeuroProtection Complex consisting of highly concentrated standardized extracts of hops, ginger, and rosemary that help suppress inflammatory cytokines.

Circulation Is key to cognitive health
Brain cells such as neurons are fed by blood vessels. Some of these microcapillaries can be so small that red blood cells carrying oxygen have difficulty passing through them.

Neurons are the key structure for cognitive functions including memory. Vinpocetine enhances blood flow by dilating blood vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism by helping to maintain healthy blood flow and glucose levels in those already within normal range, which enhances oxygen utilization.16*

Additional advanced brain nutrients
L-alpha glycerylphosphorylcholine (A-GPC), an acetylcholine precursor, is naturally present in all the body’s cells. Its importance to life and safety as a supplement are evidenced by its substantial presence in human breast milk.17,18 Acetylcholine is an essential neurotransmitter involved in muscle control, sleep, and cognition. Alpha-GPC plays a key role in both the synthesis and the catabolic recycling of phospholipids. Alpha-GPC supplementation may result in an increased rate of phospholipid synthesis, including the phosphoinositides available for signal transduction at central nervous system level.19

Acetylcholine decline coincides with advancing age, and is a hallmark of neurodegenerative decline. Cognitex provides A-GPC as a crucial building block for the production of acetylcholine in the brain.20,21

Cognitex is available with pregnenolone. Concentrations of this critical hormone are much higher in the brain, and studies show that this hormone has numerous mental benefits. All these ingredients work synergistically to promote optimal cognitex function.

Supplement Facts

Serving Size 3 softgels

Servings Per Container 30
Amount Per Serving

Alpha-Glyceryl Phosphoryl Choline (A-GPC) 600 mg

Phosphatidylserine [Sharp-PS® GOLD Conjugated Phosphatidylserine-DHA] 100 mg

Pregnenolone 50 mg

Vinpocetine 20 mg

Leucoselect® Phytosome™ [containing 50 mg grape seed (Vitis vinifera) procyanidin extract complexed with soy (Glycine max) phospholipids (bean)] 150 mg

VitaBlue® Wild Blueberry (Vaccinium angustifolium) 130:1 Extract (fruit) [std. to 4.9% Total Anthocyanins (7.35 mg)] 150 mg

Sensoril® Ashwagandha (Withania somnifera) Extract (root and leaves) [std. to 8% withanolide glycoside conjugates (10 mg)] 125 mg
Uridine-5'-Monophosphate (disodium) 50 mg

Proprietary NeuroProtection Complex Blend 125 mg
Perluxan™ Hops (Humulus lupulus) Standardized Extract (cones), Ginger (Zingiber officinale) Standardized Extract (rhizome), Rosemary (Rosmarinus officinalis) Standardized Extract (leaves)

Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, silicon dioxide, carob color, purified water.

Contains fish (wild herring, blue whiting) and soybeans. Contains rice.
This product contains NO milk, egg, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Sharp-PS® GOLD is a registered trademark of Enzymotec Ltd.
Leucoselect® is a registered trademark of Indena S.p.A.
Phytosome™ is a trademark of Indena S.p.A.
Perluxan™ is used with permission.
Sensoril® is protected under US Patents Nos. 6,153,198 and 6,713,092 and is a registered trademark of Natreon, Inc.
VitaBlue® is a registered trademark of VDF Futureceuticals, Inc.
Dosage and Use

Take three softgels in the morning with or without food.

Some people may take three softgels twice daily, or as recommended by a healthcare practitioner.
Caution

Pregnenolone may affect hormone levels so those with hormonal cancers such as prostate or breast cancer should use Cognitex without pregnenolone. Based on animal research, those with epilepsy or a predisposition of brain seizures may want to avoid pregnenolone. If you are taking Warfarin (Coumadin®), consult with your physician before using this product.

www.lef.org Reprinted with permission of Life Extension.

7. J R Soc Health. 2004 May;124(3):119-21.
8. J Agric Food Chem. 2005 May 4;53(9):3403-7.
9. Mutat Res. 2003 Feb 5;535(1):103-15.
10. Mech Ageing Dev. 2001 Nov;122(16):2025-40.
11. Isr J Psychiatry Relat Sci. 2000;37(4):302-7.
12. Altern Med Rev. 2005 Dec;10(4):268-93.
13. Brain Res Brain Res Rev. 2006 Sep;52(2):389-97.
14. Brain Res. 2007 Feb 16;1133(1):42-8.
15. J Neurochem. 2007 Nov 8; [Epub ahead of print]
16. Ideggyogy Sz. 2007 Jul 30;60(7-8):301-10.
17. Neurochem Res. 1995 Jan;20(1):1-9.
18. J Neurosci Res. 2001 Oct 15;66(2):266-71.
19. Pharmacol Toxicol. 1994 Feb;74(2):95-100.
20. J Neurosci Res. 1991 Nov;30(3):555-9.
21. Eur J Pharmacol. 1992 Jul 21;218(1):117-21.

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