Mito Charger was formulated based on the most extensive research
available to enhance mitochondrial function.
Detailed PDF document on MitoCharger at this MitoCharger
Information link.
The ingredient BenaGene ® contains a key intermediate in the
Kreb's Cycle. Studies demonstrate that benaGene mimics a caloric
restriction diet, which has been shown to increase the expression
of beneficial genes associated with increased life span, health
span, weight management and blood glucose reduction.
180 Vegi-Caps 383 mg
100% Vegetarian
SUPPLEMENT FACTS
Serving Size: 6 Capsules
R(+)-Lipoic Acid 150 mg
Co-Enzyme Q10 100 mg
Rhodiola Rosea (min 3% rosavins, 1% salidroside) 150 mg
Benfotiamine 150 mg
Oxaloacetic acid (Benagene ®)100 mg
D-Uridine 50 mg
Gymnostemma Pentaphyllum Extract 100 mg
Acetyl-L-Carnitine 1500 mg
Suggested use: Take 6 capsules daily with food, or as directed
by a qualified health care practitioner.
Source: Multi-sourced
Cautions: None known.
Pregnancy/Nursing: Do not use.
Immortality is an age old Holy Grail. A phenomenon of the ego. A
topic best left to science fiction and Hollywood. The search for it
is often beset with tragedy, as was the case of Juan Ponce De Leon
and his quest for the legendary fountain of youth.
However, life extension is a realistic goal and a proven
physiologic phenomenon in diverse organisms through various
interventions, such as exposure to certain stresses (ionizing
radiations, heat or osmotic shock) or caloric restriction.
There are several ways of extending life span but the key is to
match the gain in years with a corresponding increase in vigor and
vitality. In other words, adding years to life has to be concurrent
with adding life to years. Ideally increasing both maximal life
span and health span. The latter can be assessed by monitoring
various disease-risk markers such as lowered blood glucose levels,
Hb1Ac, isoprostane F2, reactive oxygen and nitrogen species, lipid
markers, age-amadori adducts, and different inflammatory markers
such as C-reactive proteins.
The process of aging has been ascribed to various mechanisms
including: (1) increased metabolism and thus increased production
of reactive oxygen species, (2) reduction of apoptosis (or
programmed cell death), (3) increased glucose/insulin and
insulin-like growth factor 1 (IGF-1) signaling molecules, (4)
disruption of the daf-2 pathway, (5) effect of longevity genes
(including FOXO, Sir-2, and INDY (I am not dead yet)), (6)
NAD+/NADH ratio, and others.
Caloric restriction optimal nutrition (CRON) extends life and
health span in a wide variety of organisms and has been shown to
delay the onset or reduce the incidence of many age-related
diseases, including cancers, diabetes, cardiovascular diseases and
neurological diseases (including Parkinson's and Alzheimer's).
Furthermore, a significant improvement in various disease risk
parameters has been conclusively shown in humans.
Thanks to the pioneering work of professors Leonard P. Guarente
(of the Massachusetts Institute of Technology) and David A.
Sinclair (of Harvard University), research has revealed that
certain longevity genes are activated during caloric restriction.
Moreover, their work showed that this effect was evident at any
age; in other words, life extension could be achieved in older age
groups as well. Gurante and other researchers believe that this
effect may be related to the critical ratio of the ubiquitous
co-enzymes NAD+ (the oxidized form of NAD, or nicotinamide adenine
dinucleotide) and its reduced form NADH. NAD is a niacin-derived
coenzyme that is present in all living cells and is critical to the
production of ATP - the body's primary source of all immediate
energy. Higher NAD+ levels are thought to have a stimulatory effect
on the beneficial genes whilst a high NADH concentration is thought
to inhibit such genes. Hence a high NAD+/NADH ratio may prolong
life and health span.
BenaGene ® is a novel caloric restriction mimetic (CR mimetic).
It mimics the changes in the expression of over 350 genes in a
similar fashion to caloric restriction and thus may be considered a
true nutrigenomic compound. The resulting (and astonishing)
increases in average and maximal life span, reduction in weight,
and reduction in glucose levels have been observed in various
species.
Human clinical trials have confirmed both reduction in glucose
levels and an improved uptake of glucose without negative side
effects (and hence an effective hypoglycaemic agent). BenaGene work
on a "biological diode" thereby increasing the conversion of NADH
to NAD+ as well as on resulting changes in the electrical state
(Gibbs free energy) and critical signaling molecules.
BenaGene is the world's first novel and natural Krebs cycle
intermediate compound that is specifically formulated to be highly
stable and bio-available so that a one-a-day dosage is all that is
required, offering the potential of life and health extension.
The Importance of the Mitochondria The cell is the basis of all
life, and the mitochondrion is the power plant that keeps the cell
operating. A simple but effective metaphor for what is one of the
most significant and complex biochemical relationships known to
science. Without mitochondria, cells simply do not produce the
energy(in the form of ATP) needed for the human body to function or
even survive. It comes as little surprise, therefore, that any
state of mitochondrial dysfunction can be associated with a host of
metabolic conditions, including Type II Diabetes, Syndrome X and
excessive free radical production.
Boosting Mitochondrial Function Many natural compounds have been
shown to help support mitochondrial function, thereby helping to
counteract mitochondrial dysfunction. These compounds include
antioxidants like R(+)-Lipoic acid, as well as key molecules like
Co-enzyme Q10, which are involved in ATP production. Vitamin B1,
the herb Rhodiola Rosea, D-uridine, Gynostemma pentaphylum,
oxaloacetic acid and acetyl-L-carnitine also help to support
mitochondrial function through a variety of mechanisms.
AOR’s Mitocharger provides an advanced and effective formula to
help support the mitochondria and to counteract aging associated
with mitochondrial deficiencies
Copyright © 2009, Advanced Orthomolecular Research
