OBP Advanced Bone Protection

OBP Advanced Bone Protection™ contains MBP, an active protein complex from the whey fraction of milk. Research suggests that MBP can positively impact bone health by reducing bone loss (resorption) and increasing bone mineral density.

30 Vegi-Caps 40 mg AOR08111

SUPPLEMENT FACTS:
Serving Size: 1 Capsule

MBP† (A specific basic protein fraction derived from milk) ...... 40 mg

† MBP™ is owned by Snow Brand Milk Products Co., Ltd. in Canada
Non-medicinal Ingredients: Microcrystalline cellulose. Capsule: hypromellose, sorbitol, silicon dioxide, water.


AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, soy, eggs, fish or shellfish.

Suggested Use
Take one capsule daily with/without food or as directed by a qualified health care practitioner.

Main Applications
* Supports skeletal health

Source
Bovine Milk.

Pregnancy / Nursing
No studies, best to avoid.

Cautions
Advanced Bone Protection™ is not recommended for people with milk allergies.

What Is Advanced Bone Protection™ ?

Milk in general (and bovine milk in particular) arguably contains more growth factors than any other single food source. Growth factors are specific proteins which act as intracellular signaling molecules. Scientists in Japan have isolated a fraction from whey protein which they have determined to have positive metabolic effects on bone health. It is called Milk Basic Protein, or MBP®, and it is the active ingredient in Advanced Bone Protection from AOR™.

How Does Advanced Bone Protection™ Work ?

Stated very briefly, MBP stimulates the activity and proliferation of osteoblasts (bone-building cells) while simultaneously suppressing the activity and proliferation of osteoclasts (cells responsible for the resorption – or breakdown – of bone). MBP is particularly effective at supporting the production of collagen as well as the retention of calcium.

At first glance, the mechanism of action through which MBP exerts its effects seems remarkably similar to that of its bone-enhancing nutrient predecessors such as calcium, vitamin D and strontium. For example, MBP assists in the absorption and retention of calcium, just as vitamin D does. Unlike vitamin D, however, MBP does so via the inhibition of cystein protease due to the presence of the protein strain known as cystatin C, which is part of the structure of MBP itself. Cystatin C also inhibits the release of calcium from bones stimulated by thrombin, interleukin-1 and prostaglandin E2. The essential nature of this function cannot be understated, as calcium can metaphorically be referred to as the mortar for the infrastructure that is collagen - together contributing to form the complex that is bone.

Cystein protease also digests collagen in the bone matrix, further testimony to the benefit of its inhibitory effect from the cystatin C contained in MBP. MBP cultivates both the proliferation and activity of the bone-building osteoblasts while conversely bridling the same proliferation and activity among the osteoclasts responsible for the resorption (breakdown) of older bone tissue. Even more revealing is the extent of MBP’s inhibition of osteoclasts, suppressing the activity of even the most isolated osteoclast cells. The association between the osteoblast/osteoclast relationship and collagen lies in the ability of osteoblasts to produce collagen, and it is here where MBP comes into its own. The ability to specifically manipulate osteoblasts into producing more collagen in a manner that is more pronounced than that of its osteo-nutrient predecessors is an additional factor that makes MBP unique. Furthermore, MBP also increases serum concentrations of osteocalcin (BGP, also called Gla protein), which is the major non-collagenous protein in bone.


Science In Action: What The Studies Say

As with all promising nutraceutical innovations, early in-vitro research revealed encouraging indications of what would later become identified as MBP. Indeed, such indications at the in-vitro level need to be encouraging in order to secure further, in-vivo studies. This preliminary research identified whey protein as having an exemplary influence on the relationship between osteoblasts and osteoclasts. It was discovered that in addition to fortifying osteoblasts, whey protein was also shown to suppress osteoclast-mediated bone resorption and osteoclast cell formation. This began a lengthy scientific process to isolate the fraction of whey protein that scientists believed was responsible for these bone-reinforcing effects. MBP was the eventual result of that process.

The recent scientific isolation and practical procurement of MBP has lead to numerous studies with excitingly impressive results. The first study among humans involved thirty-three healthy women who were randomly assigned to treatment with either a placebo or MBP (40 mg per day) for six months. The bone mineral density (BMD) of the left heel bone of each subject was measured at the beginning of the study and at the end. Serum and urine indices of bone metabolism were measured at the base line, threemonth intervals, and again at the end of the study. When standard BMD testing was conducted at the end of the study, the women in the MBP group gained approximately 70% more bone mineral density than the control group. Furthermore, urinary markers of bone loss - in this case, cross-linked type- I collagen/creatinine and deoxypyridinoline/creatinine, were 'significantly decreased' in the MBP group.

A study among healthy adult men was similarly impressive, as well as another study among healthy adult women in 2002. This particular double-blind, placebo-controlled trial measured radial bone mineral density, and once again the mean BMD value of the MBP group was 'significantly higher' than that of the placebo group.

A Summary of the Results of MBP Studies:
• In a study among healthy menopausal women, the MBP group reported a bone mineral density (BMD) increase of 1.21% while the placebo group recorded a 0.66% BMD decrease.
• In another study among healthy adult women, the MBP group gained approximately 70% more bone mineral density than the control group.
• MBP reduced the number of pits on the bone surface caused by bone resorption by approximately 85% in an in-vitro study.
• In yet another study among healthy adult females, the MBP group displayed a 3% increase in the BMD of the radius (a forearm bone near the wrist) compared to a 1.3% BMD decrease in the placebo group.

Finally, the MBP in Advanced Bone Protection™ from AOR comes in small, convenient capsules that can be taken with or without food and have no interactions with calcium or any other nutrients.

References

Aoe S, et al. A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women. Osteoprosis International. 2005 Dec;16(12):2123-8. Epub 2005 Aug 31.

Aoe S, et al. Controlled Trial of the Effects of Milk Basic Protein (MBP) Supplementation on Bone Metabolism in Healthy Adult Women. Biosci. Biotechnol. Biochem. Vol.65 pp.913-918. 2001.

Matsuoka Y, et al. Cystatin C in Milk Basic Protein (MBP) and Its Inhibitory Effect on Bone Resorption in Vitro. Biosci. Biotechnol. Biochem. 2002. Vol.66 pp.2531-2536.

Takada Y, et al. Milk Basic Protein Increases Bone Mineral Density and Improves Bone Metabolism In Humans. Nutritional Aspects of Osteoporosis 2nd Ed. (2004); pp. 413-429.

Toba S, et al. Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men. Biosci. Biotechnol. Biochem. Vol.65 pp.1353-1357. 2001

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