Resveratrol RevGenetics X500

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Supplement Facts:
100% Vegetarian Capsules
30 Capsules

Polygonum Cuspidatum extract (from root) 500mg *
(supplying 495mg trans-resveratrol)
*daily value not established.

Other ingredients:
vegetable cellulose, magnesium octadecanoate

Directions: Although a daily dose has not been established, for adults the manufacturer recommends taking 1-4 capsules daily. No more than 1 for every 50lbs of body weight.

Warning:
Pregnant or lactating women should consult a doctor before using any product. Consult a doctor before use if you have, or have had, any health condition or if you are taking any medicines or remedies including OTC medications or are planning any medical procedure.

X500 - 30 Capsules, 500mg, 99% Polygonum Cuspidatum (resveratrol) Extract per capsule

Following Information courtesy of, and copyright, Revgenetics.com

Each Resveratrol Capsule = 250 Bottles of Wine.
Resveratrol 99% Powder - Each 500mg capsule contains 495mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant.

Recommended Dosage:
Two or more capsules a day, but no more than two capsules per 100lbs of personal weight per day.

The following mentions research done in animals and in labs. We do not claim our products will act in a similar fashion in regular people. As a dietary supplement company, we only present the information for your consideration.

Why a 500mg Capsule?
Because 100mg is fine for mice, but it is simply too low for humans:

About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolized in intestines and liver into conjugated forms: glucuronate and sulfonate.[1] Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5 g) was given as uncoated pill, the concentration of resveratrol in blood was only 2.4umol/L.[2]

[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).

[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).

What about the stability of Resveratrol?
Resveratrol has been found to be stable. The trans- form can undergo isomerisation to the cis- form when exposed to ultraviolet irradiation.[3] Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 degrees C in the presence of air.[4] Resveratrol content also stayed stable in the skins of grapes and pomace taken after fermentation and stored for a long period.[5]

[3]. "Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).

[4]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).

[5]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).

Does It Work ?
Resveratrol is one of 3 supplements we are working on for longevity. Resveratrol is aimed at the P53 gene along with many other benefits. Astral Fruit is specifically aimed at the Telomerase gene. A third supplement that we have not yet made available is aimed at the P16 gene. We believe maintaining these 3 genes in a healthy state will allow a person to naturally live healthier for a longer period of time.

We have looked through the literature, and there have only been small human studies regarding resveratrol. There are no clinical studies regarding longevity in humans, as it may take 20 years or more to produce a longevity study. The only thing we can do is discuss current animal studies, and see how they may or may not relate to humans. Because of all the positive information from hundreds of studies in animals and in lab cells, it is believed that this maybe one of the most complex and beneficial herbal supplements available.

Are there any cautions I should be aware of?
In studies, resveratrol is suggested to be a weak inhibitor of the P450 3A4 liver metabolism system, which is of unknown significance for humans. Taking large amounts of resveratrol may increase blood levels of drugs that are usually metabolized by CYP3A4. This simply means that calcium channel blockers, statins, some immunosuppressant drugs (like cyclosporine), and erectile dysfunction drugs such as sildenafil, may have increased blood levels. Please be cautious when taking resveratrol with anticoagulants or anti platelet drugs such as Plavix(r) (Clopidogrel). An increase in adenosine availability is involved in resveratrol cardioprotection in rats. It maybe possible that an increase in adenosine can increase uric acid temporarily. As a caution, it is not recommended long term for people with a genetic predisposition to Gout.

We also advise the following:

* Keep out of reach and do not give to children.
* Do not exceed suggested maximum dose unless your doctor recommends it.
* If you have a bad reaction to the supplement discontinue use immediately.
* When undergoing treatment for any medical condition, are pregnant (or lactating) please inform your physician when using any nutritional supplements.


All natural herbal extract from plant root. We only use vegetarian capsules. The oxygen in all bottles have been reduced to 0.02% or less, to eliminate oxidation. Herbal powder is independently tested in a United States laboratory for safety and purity. Herbal powder has been independently verified to activate the SIRT1 Gene as good as, or better than research grade Resveratrol. Made in the USA.

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