<H1>Acetyl-L-Carnitine: Consider Geronova Carnitine Plus Instead -- Relentless Improvement LLC Shopping Cart</H1>
<I>DISCONTINUED- Purchase Geronova Carnitine Plus as a fine replacement.</I>
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DISCONTINUED- Please purchase Geronova Carnitine Plus as a fine replacement.<BR><BR>500mg x 180 capsules <BR><BR>ALCAR (acetyl-l-carnitine) is your cellular supercharger. Extensive research has documented ALCAR's ability to rejuvenate mitochondrial bioenergetics and support cognitive function. ALCAR should always be taken in combination with R(+)-Lipoic Acid (not the common "alpha-lipoic acid" or "lipoic acid") for additive benefits and to reduce metabolic byproducts created by aging mitochondria.<BR><BR>We recommend GeroNova Research R+ and R-DiHydro-Lipoic Acids for their bioavailability.<BR><BR>Acetyl-L-carnitine has recently demonstrated some efficacy as a possible neuroprotective agent and may be indicated for use in strokes, Alzheimer's disease, Down's syndrome and for the management of various neuropathies. It may also have anti-aging properties. Research regarding acetyl-L-carnitine's possible beneficial effect on sperm motility is early-stage but promising.<BR><BR>Breaking News<BR><BR>L-carnitine protects brain DNA from age-related damage<BR><BR>A report published in the January 2005 issue of the journal Experimental Neurology revealed that the amino acid L-carnitine helps protect the brain of rats from the DNA damage that occurs with aging. <BR><BR>Dr P. A. R. Juliet of Nagoya University in Japan and colleagues gave 4 month old and 24 month old rats 300 milligrams acetyl-L-carnitine per kilogram body weight for 7, 14 and 21 days following which their brain cortex, hippocampus, striatum, hypothalamus and cerebellum were examined for antioxidant enzyme activity, nucleic acid (DNA and RNA) levels, and DNA damage. <BR><BR>Carnitine levels were lower in all brain regions examined in the 24 month old rats than in the 4 month old animals, although longer supplementation with L-carnitine was reflected in increased brain levels of the amino acid in the older animals, which was not observed in the younger rats. Older rats also had lower brain levels of the antioxidant enzymes superoxide dismutase and glutathione peroxidase, as well as lower DNA and RNA levels in the cortex, hippocampus and striatum, however in older rats who received L-carnitine, the researchers found enhanced levels of antioxidants and nucleic acids that increased with duration of the treatment, which again, were not found to be effected by carnitine in the younger rats.<BR><BR>When DNA damage was assessed, it was found to be higher in the older rat brains than in the younger rats, particularly in the cortex, hippocampus and striatum, and carnitine was shown to provide the greatest protection against damage in these areas. L-carnitine did not significantly reduce brain DNA damage in young rats. <BR><BR>The authors propose that L-carnitine provides its neuroprotective effect by promoting energy production, activating a DNA repairing enzyme and enhancing antioxidant status.<BR><BR>Several studies have now demonstrated some positive effects of acetyl-L-carnitine supplementation in Alzheimer's patients especially with regard to tasks involving attention and concentration. In a double-blind, parallel design, placebo-controlled pilot study of 30 patients whose mild-to-moderate dementias were believed to be symptoms of Alzheimer's disease, there were significant, positive results as measured by some of the neuropsychological tests used in the study.<BR><BR>More recent studies continue to show beneficial effects in Alzheimer's disease. Younger patients seem to benefit most.<BR><BR>There is some evidence in animal work that acetyl-L-carnitine might have anti-aging effects. Mitochondrial function and ambulatory activity were assessed in a study of old rats fed acetyl-L-carnitine. Ambulatory activity was significantly increased in the old rats, and an examination of liver cells in the treated animals showed a significant reversal of age-associated decline of mitochondrial membrane potential. Cardiolipin, which declines with age, was significantly restored.<BR><BR>This product may not be shipped to Canada where is is regulated as a drug.<BR><BR>Adult Dosage: Take 3-6 caps daily, or as directed by a qualified health consultant.<BR><BR>180 capsules<BR>Serving Size: One capsule<BR><BR>Ingredients:<BR>N-Acetyl-L-Carnitine HCl 500mg *Dietary Reference Intake not established<BR><BR>Other ingredients:<BR>microcrystalline cellulose<BR>Capsule:<BR>vegatarian (hydroxypropymethylcelluse)<BR><BR>AOR guarantees that no ingredients not listed on the label have been added to this product.</P>
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