<H1>Super Carnosine -- Relentless Improvement LLC Shopping Cart</H1>
<I>Super Carnosine: This combination of taurine, carnosine, benfotiamine (unique synthetic variant of vitamin B1), and vitamin B1 provides a multifaceted, body-wide shield against increased aging caused by glycation.*</I>
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Super Carnosine<BR>500 mg, 90 capsules<BR>Item Catalog Number: 1287<BR><BR>Carnosine is a multifunctional dipeptide made up of a chemical combination of the amino acids beta-alanine and L-histidine. It is found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine. Muscle levels of carnosine correlate with the maximum life spans of animals.1-8<BR><BR>Carnosine is a naturally occurring antioxidant that has been shown to be an anti-glycating agent. This nutrient also has the ability to suppress advanced glycation end products (AGEs) and inhibit the formation of reactive oxygen species, a culprit in oxidative stress that can lead to age-related conditions.25<BR><BR>Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function.26<BR><BR>Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes.27*<BR><BR>Aging causes irreversible damage to the body’s proteins. The underlying mechanism behind this damage is glycation. A simple definition of glycation is the crosslinking of proteins and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as unsightly wrinkled skin. Glycation is also an underlying cause of age-related catastrophes including neurologic, vascular, and eye problems. Carnosine is a unique dipeptide that interferes with the glycation process.28<BR><BR>The combination of carnosine, benfotiamine (a fat soluble form of vitamin B1), and vitamin B1 provides a multifaceted, body-wide shield against increased aging caused by glycation.<BR><BR>Supplement Facts<BR>Serving Size 1 capsule<BR>Servings Per Container approx. 90<BR><BR>Amount Per Serving<BR><BR>Thiamine (vitamin B1) (as thiamine HCI) 50 mg<BR>Carnosine 500 mg<BR>Benfotiamine 50 mg<BR>Luteolin (from Perilla leaf extract) (Perilla frutescens)] 4 mg<BR><BR>Other ingredients: gelatin, magnesium stearate.<BR><BR>This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.<BR> <BR>Dosage and Use <BR>Adults, take two or three capsules per day, or as recommended by a healthcare practitioner. <BR> <BR>This product can be taken with or without food.<BR><BR>Caution <BR>Do not use during pregnancy or lactation.*<BR> <BR>Warnings:<BR>Keep out of reach of children.<BR>Do not exceed recommended dose.<BR>Do not purchase if outer seal is broken or damaged.<BR>If you have a bad reaction to product discontinue use immediately.<BR>When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.<BR><BR>www.lef.org Reprinted with permission of Life Extension.<BR><BR>1. Physiol Rev.1998 Apr;78(2):547-81. http://physrev.physiology.org/cgi/content/full/78/2/547<BR>2. Ann N Y Acad Sci. 2004 Jun;1019:406-11.<BR>3. Age. 1983 6:86-94.<BR>4. Exp Gerontol. 1984; 19: 31-36.<BR>5. Proc Natl Acad Sci USA. 1994; 91:10771-8.<BR>6. Proc Natl Acad Sci USA. 1997; 94:3064-9.<BR>7. Ann NY Acad Sci. 1998; 854:118-127.<BR>8. Brain Res. 1990 Aug 27;526(1):108-12.<BR>9. Metabolism. 1997 Dec;46(12):1454-7.<BR>10. Mech Ageing Dev. 1995 Oct 13;84(2):103-12.<BR>11. Ann N Y Acad Sci. 2002 Apr;959:491-507.<BR>12. Physiol Rev. 1983 Oct;63(4):1420-80.<BR>13. World J Gastroenterol. 2005 Dec 7;11(45):7197-202.<BR>14. J Neurosci Res. 2006;84(2):398-408.<BR>15. Acta Diabetol. 2003 Oct;40 Suppl 1:S106-S113.<BR>16. Biophys Acta. 2000 Jun 26;1486(1):1-17.<BR>17. Int J Cardiol. 2006 Feb 8;107(1):54-60.<BR>18. Alzheimer Dis Assoc Disord. 1995;9(3):128-31.<BR>19. Neurochem Res. 1995 Jan;20(1):1-9.<BR>20. Mol Cell Biochem. 2003 Dec;254(1-2):227-34.<BR>21. Neurochem Res. 1995 Jan;20(1):1-9.<BR>22. J Neurosci Res. 2001 Oct 15;66(2):266-71.<BR>23. J Neurosci Res. 1991 Nov;30(3):555-9.<BR>24. Eur J Pharmacol. 1992 Jul 21;218(1):117-21.<BR>25. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.<BR>26. Arch Gerontol Geriatr. 1999. 29: 107-113.<BR>27. Am J Physiol. 1997; 272(1 Pt 2):H462-H468.<BR>28. Biogerontology. 2005;6(2):147-9.</P>
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<LI>SKU: 1287
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