<H1>Sulforaphane -- Relentless Improvement LLC Shopping Cart</H1> <I>Sulforaphane and 6-MITC have been documented to induce the Phase-2 detoxification enzyme system.</I> <P> <IMG SRC="https://store.nexternal.com/relentless/images/Sulforaphane.jpg" ALIGN=right ALT="Sulforaphane" NAME="Sulforaphane" BORDER=0 HSPACE=10> Sulforaphane + contains sgs and wasabia japonica extract. sgs is a patented broccoli seed concentrate rich in glucoraphanin, which is converted into the isothiocyanate sulforaphane. Wasabia japonica contains similar isothiocyanates such as 6-MITC. Sulforaphane and 6-MITC have been documented to induce the Phase-2 detoxification enzyme system.<BR><BR>30 Vegi-Caps 380 mg AOR08144<BR><BR>SUPPLEMENT FACTS:<BR>Serving Size: 1 Capsule<BR><BR>sgs&#8482; (standardized to contain 30 mg<BR> glucoraphanin glucosinolate) ..... 300 mg<BR>Wasabia japonica extract ....... 80 mg<BR><BR><BR>Non-medicinal ingredients: none. Capsule: hypromellose, sorbitol, silicon dioxide, water.<BR><BR>Product produced under Canadian patent 2,232,488 licensed from Brassica Protection Products LLC. sgs&#8482; is a trademark of Brassica Protection Products LLC.<BR><BR>AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no corn, wheat, gluten, nuts, dairy, soy, eggs, fish or shellfish.<BR><BR>Suggested Use<BR>Take 1 capsule daily with/without food, or as directed by a qualified health practitioner. Do not use if pregnant or breastfeeding.<BR><BR>Pregnancy / Nursing<BR>None.<BR><BR>Cautions<BR>None.<BR><BR>Imagine a cell that never dies and replicates without end - such cells exist; an eternal cell that replicates uncontrollably is a cancer cell. Cancer develops when the machinery that induces the cellular death of abnormal cells (apoptosis), is inactivated. The answer to the treatment of cancer is to reactivate cellular apoptosis or to improve the function of the immune system so that it can target and destroy abnormal cells.<BR><BR>Several nutrients found in our diet have been shown to possess anticarcinogenic properties. For example, cruciferous vegetables contain indoles and isothiocyanates, and high intakes of cruciferous vegetables have been associated with lower risk of lung and colorectal cancer in epidemiological studies. Other nutrients can prevent the development of cancer, support our immune system and improve the cellular processes that lead to apoptosis. <BR><BR>Researchers have determined that in the 22-year span from 1981 to 2002, 62% of new cancer treatments were of natural origin. Natural ingredients can and have played an important role in the prevention and treatment of cancer. <BR><BR>Two nutrients that have attracted considerable scientific interest with regards to abnormal cellular differentiation and growth are broccoli sprouts and wasabi extracts. The anticarcinogenic properties of both plants come from their isothiocyanate content: Sulforaphane and 6-methylsulfinylhexyl isothiocyanate (6-HITC) &#8211; respectively. 6-HITC is also a sulforaphane analogue. Sulforaphane is the most characterized isothiocyanate.<BR><BR>Sulforaphane is a natural compound found in broccoli sprouts that has been shown to inhibit tumor formation. Sulforaphane extracts have several benefits for cancer patients. These include:<BR><BR>&#8226; Protecting DNA from mutagens<BR>&#8226; Inhibiting the cellular proliferation of neoplastic cells<BR>&#8226; Inducing apoptosis in cancer cells<BR>&#8226; Impeding the progression of benign tumors into malignant tumors<BR>&#8226; Preventing metastasis (cancer spread)<BR>&#8226; Inhibiting the formation of new blood vessels (angiogenesis) which feed tumors<BR>&#8226; Stimulating the immune system<BR><BR>Sulforaphane induces several cellular signals that lead to apoptosis in cancer cells. Animal studies also demonstrate that sulforaphane improves the immune response. Sulforaphane also increases the production of immune cells in the bone marrow and leads to higher levels of circulating antibodies. <BR><BR>Furthermore, sulforaphane improves macrophage and natural killer cell activity. The latest research confirms that sulforaphane is a promising agent to prevent, treat and reverse cancer. Sulforaphane acts against a variety of cancer types and is helpful at early, intermediate or late stages of the disease.<BR><BR>Wasabi (Wasabia japonica syn. Eutrema japonica) or Japanese horse radish, is a highly valued plant in Japanese cuisine and is a member of the brassicacea family which includes over 3000 species. These include Brussels sprouts, broccoli, mustard, cabbages and many others. Wasabi is a condiment traditionally served with raw fish (sushi and sashimi) and noodle (soba) dishes in Japan. The ground root-like rhizome pungently flavours many other foods in Japanese cuisine and its bright green colour provides for a palliative colour contrast, something for which Japanese dishes are famous. In the last twenty years, because of the low supply of fresh wasabi rhizomes, substitutes made of mixtures of horseradish, mustard and food colouring have often taken the place of freshly prepared wasabi. <BR><BR>However, true wasabi plant extract (as contained in Sulforaphane +&#8482;) has been shown to combat carcinogenesis by inhibiting cellular proliferation, scavenging free radicals and inducing apoptosis. Wasabi contains unique groups of long chain isothiocyanates (not commonly found in traditional foods) and are associated with inducing Phase one and Phase II detoxification enzymes. <BR><BR>In addition, wasabi is an effective scavenger of reactive oxygen species (ROS), an important point to consider since most chronic diseases are thought to be associated with ROS to some degree or another. The isothiocyanates within the wasabi plant, particularly 6-HITC, is considered to be up to 40 times more potent than more common isothiocyanates found in such sources as cabbage, Brussels sprouts, and mustard seeds.<BR><BR>The research on isothiocyanates from wasabi and broccoli has shown that they are ideal for those whose cellular function has gone unchecked and for those whose immune system has been unable to keep up with the inner turmoil engendered by the development of cancer. Indeed, as concluded in one study on sulforaphane, the nutrient can &#8220;prevent, delay, or reverse preneoplastic lesions, as well as to act on cancer cells as a therapeutic agent.&#8221;<BR><BR>References<BR><BR>Fimognari C, Hrelia P. Sulforaphane as a promising molecule for fighting cancer. Review. Mutat Res. 2007 May-Jun; 635(2-3): 90-104.<BR><BR>Jin, CY et al. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis. 2007 May;28(5):1058-66.<BR><BR>Hasegawa, N et-al. Comparison of effects of Wasabi japonica and allyl isothiocyanate on the growth of four strains of Vibrio parahaemolyticus in lean and fatty tuna meat suspension. Int. J. Food. Micro. 1999:49;27-34.<BR><BR>Das, S et-al. Cancer modulation by glucosinolates: A review. Curr. Science. 2000:79;1665-1671.<BR><BR>Kinae,N et-al. Functional properties of wasabi and horseradish. 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