<H1>Strontium Support / Strontium Citrate -- Relentless Improvement LLC Shopping Cart</H1>
<I><b>**Discontinued**This product replaced by Relentless Improvement brand Strontium Citrate. </b></I>
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<b>**Discontinued** This product replaced by Relentless Improvement brand Strontium Citrate (340 mg x 120 capsules)</b>
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Strontium Support is Strontium Citrate, an organic, stable strontium form (not the radioactive strontium-90 isotope!).
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Strontium is a trace mineral in the diet whose metabolism is closely tied to that of calcium, and which concentrates in the skeletal system, where it supports the function of osteoblasts (the cells which form new bone) while reducing the differentiation and activity of osteoclasts (the cells which resorb old bone).
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Extensive evidence supports a role for strontium citrate in skeletal health.
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90 Vegi-Caps AOR04036
100% Vegetarian
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SUPPLEMENT FACTS: <br>
Serving Size: 1 Capsule %DRI<br>
Strontium (citrate) ……… 227 mg *<br>
(Providing 227mg elemental)<br>
*Dietary Reference Intake not established. <br>
Other ingredients: none. <br>
Capsule: vegetarian hydroxypropylmethylcellulose).
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AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, or shellfish.
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Suggested Use<br>
Take one to three capsules daily on an empty stomach, one hour before breakfast and/or three hours after the last meal of the day, or as directed by a qualified health consultant. Ensure that calcium intake is also adequate, but do not take at the same serving time as calcium supplements.
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Main Applications<br>
As reported by literature:<br>
•Supports skeletal health.
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Pregnancy / Nursing: No studies have been conducted. Best to avoid.
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Cautions: Ensure calcium intake is also adequate. Do not take at the same time as calcium supplements.
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Key Ingredients: Strontium citrate
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Related Research of Strontium Support
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Strontium- The First Bone-Building Supplement!
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Bone loss accelerates suddenly in menopausal women because the drop in estrogen levels causes an increase in the resorption (teardown) of existing bone. But resorption is only half of the story. Age-related bone loss is also caused by a decrease in the formation of new bone tissue.
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Existing drugs for treating osteoporosis, as well as calcium and vitamin D supplements, work by reducing bone resorption. But they do not support the formation of new bone. These drugs and nutrients increase the mineralization of bone, but they do not help the body to build new bone tissue. And in fact, within weeks of starting use of antiresorptive drugs like Fosamax,® the body’s formation of new bone actually decreases. The resulting bone is less prone to fracture, but is not the same as youthful, healthy bone.
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Strontium is a mineral found along with calcium in most foods. Research has long suggested that it may be an essential nutrient required for the normal development, structure, function, and health of the skeletal system. Clinical trials going back into the 1940s have supported this conclusion, but recent studies have provided evidence that it can offer unique nutritional support against loss of bone structure and function.
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Animal studies have shown that Strontium supplements both decrease bone resorption, and increase the formation of new bone tissue.
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•In animal models, Strontium (in various forms, such as chloride, carbonate, and ranelic acid salt) causes “baby” osteoblasts (bone-building cells) to multiply more quickly.<br>
•Bone tissue cultures which are exposed to Strontium synthesize more bone matrix and new bone collagen. The same amount of calcium (in various forms, including the ranelic acid salt) has no effect on these parameters.<br>
•In bone tissue culture, Strontium reduces bone resorption at concentrations at which calcium has no effect, prevents the resorption caused by excessive parathyroid hormone, and slows the rate at which immature osteoclasts develop.<br>
•Strontium-supplemented diets boost bone strength in experimental animals without a negative impact on bone quality, even at extremely high doses.
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Human clinical trials also support Strontium’s ability to both support new bone formation and prevent excessive resorption.
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•The results of early clinical trials using Strontium (lactate) led researchers to speculate that Strontium increased osteoblast activity. <br>
•Bone biopsies from a small human pilot trial revealed an astounding 172.4% increase in new bone formation after six months of Strontium (gluconate) supplementation.<br>
•The bone-building activity of osteoblasts can be measured using bone-specific alkaline phosphatase, while crosslinked N-telopeptide (NTx) and C-telopeptide (CTx) mark the degradation of bone collagen by ravaging osteoclasts. The use of these tests in large clinical trials (using the ranelic acid salt of Strontium) has confirmed that Strontium supplements decrease bone resorption and also stimulate bone-building osteoblast activity and new bone formation in women with osteoporosis.
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Recent large-scale, double-blind, placebo-controlled trials using the ranelic acid salt of Strontium have proven that Strontium supplements combined with calcium and vitamin D dramatically build bone mass, reduce the incidence of spinal deformities, and slash hip fracture risk compared to calcium and vitamin D alone.<br>
•In a three-year trial involving 1649 women with postmenopausal osteoporosis, women receiving only calcium and vitamin D suffered the loss of 1.3% of their lower spinal BMD, while women also taking Strontium supplements at 680 milligrams per day increased their bone mass by an astounding 14.4% at the spine, and by 8.3% in the large bone at the top of the thigh.<br>
•Women taking Strontium supplements were spared 41% of the new vertebral fractures that befell women taking calcium and vitamin D alone.
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A second trial showed that Strontium supplements are just as effective against hip fractures. In this study, 5091 postmenopausal women with osteoporosis received calcium and vitamin D supplements, along with 680 mg of Strontium or a dummy pill. Taking Strontium supplements allowed women to avoid 41% of the hip fractures suffered by women taking only calcium and vitamin D. Although it was a three year study, the benefit began to manifest in just a year and a half.
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A third trial shows that Strontium supplements can also protect the bones of women who do not yet have osteoporosis. In this study, 160 women in early menopause, but without osteoporosis, took either calcium supplements alone, or calcium plus Strontium for two years.
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•Women taking calcium alone were subjected to a loss of 0.5% of their
lumbar bone mass per year, but women taking calcium plus Strontium (340 milligrams daily) experienced a 0.66% gain annually. The net benefit to Strontium users was 2.46% more lumbar bone mass by the end of the trial. Lower doses (42.5 or 170 milligrams of elemental Strontium) were not effective. <p>
•Likewise, women adding Strontium to their supplement regimen experienced gains of 2.46% in bone mass at the neck of the femur, and 3.21% in the hip as a whole, compared to women taking calcium alone. <p>
•Strontium users’ lab tests revealed significant increases in markers of bone formation, with no change in markers of bone resorption.
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Unlike the range of side-effects that accompany antiresorptive drugs, no clinical side-effects have ever been reported that could be clearly attributed to Strontium. Transient changes in some laboratory tests have been observed in some studies but not others, and in one study people experienced no symptomatic, chemical, or physiological signs of toxicity after taking Strontium supplements for as long as four years, at two and a half times the dose of elemental Strontium that’s used in today’s clinical trials. In studies where laboratory changes have been observed, none have been associated with real-world clinical problems, and most have reversed themselves over the course of the study.
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Calcium and Strontium: the Dynamic Tension
Calcium and Strontium can both play key roles in the health of your bones – if you use them properly. On the one hand, animal studies suggest that Strontium is not effective, and may even be counterproductive, if your calcium intake is not adequate. Current “official” recommendations suggest an intake of 1000 milligrams of calcium for younger adults, and 1200 milligrams for people over the age of 50. Some evidence suggests that a still higher intake (1300-1600 milligrams) of calcium is more effective for lowering fracture risk in the elderly. But remember that these numbers are your total calcium need. The more calcium you get in your diet, the less you need from supplements.
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At the same time, however, it’s important not to take your Strontium supplement at the same time as your calcium supplements. This is because calcium and Strontium use the same pathways for absorption in the intestinal tract, so that swallowing a calcium supplement along with your Strontium can dramatically reduce absorption. So obviously, putting Strontium and calcium in the same pill is a recipe for bone health disaster, in which you don’t get the benefits of either nutrient!
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The best protocol – and the one used in the most recent clinical trials – is to take your Strontium either three hours after your last meal of the day, or one hour before breakfast in the morning, or both. Because studies suggest that one last dose of calcium just before retiring can help prevent excessive resorption of bone overnight, it may be best to take all of your Strontium before breakfast, leaving you free to take a calcium supplement just before you go to bed.
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Like the Strontium carbonate crystals (strontianite) from which it was first isolated,
Strontium’s role in bone health has long been hidden in obscurity. But its strength has allowed it to endure, waiting for the day that it could emerge and reveal its power.
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References<br>
Shorr E, Carter AC. The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis. 1952 Apr; 13(1): 59-66.<br>
McCaslin FE Jr, Janes JM. The effect of strontium lactate in the treatment of osteoporosis. Proc Staff Meetings Mayo Clin. 1959; 34(13): 329-34.<br>
Marie PJ, Skoryna SC, Pivon RJ Chabot G, Glorieux FH, Stara JF. Histomorphometry of bone changes in stable strontium therapy. Trace Subst Env Health. 1985; 19: 193-208.<br>
Reginster J-Y, Sawicki A, Devogelaer JP, Padrino JM, Kaufma JM, Doyle DV, Fardellone P, Graham J, Felsenberg D, Tulassay Z, Soren-Sen OH, Luisetto G, Rizzoli R, Blotman F, Phenekos C, Meunier PJ. Strontium ranelate reduces the risk of hip fractures in women with postmenopausal osteoporosis. Osteoporos Int. 2002 Nov;13 (Suppl 3): S14(AbsO14).<br>
Meunier PJ, Roux C, Seeman E, Ortolani S, Badurski JE, Spector TD, Cannata J, Balogh A, Lemmel EM, Pors-Nielsen S, Rizzoli R, Genant HK, Reginster JY. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004 Jan 29;350(5):459-68.<br>
Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int. 2001 Sep; 69 (3): 121-9.<br>
Reginster JY, Deroisy R, Dougados M, Jupsin I, Colette J, Roux C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS Trial. Osteoporos Int. 2002 Dec; 13 (12): 925-31.
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This information is copyright the Editor of Advances magazine and may not be reproduced in whole or in part in any medium without the express permission of Advanced Orthomolecular Research. Used with permission.<p></P>
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