<H1>Mitochondrial Energy Optimizer -- Relentless Improvement LLC Shopping Cart</H1>
<I>Mitochondrial Energy Optimizer provides antioxidant support to protect cells against free radical damage and glycation, supports mitochondrial energy production and cellular function.</I>
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Mitochondrial Energy Optimizer<BR>120 capsules<BR>Item Catalog Number: 01268<BR><BR>The loss of cellular vitality is caused by a number of factors, including mitochondrial problems, glycation, and free-radical reactions. Life Extension® members have access to a state-of-the-art nutritional formula called Mitochondrial Energy Optimizer that protects delicate cellular structures and enables cells to perform life-sustaining metabolic processes.<BR>Glycation and Aging<BR><BR>As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form nonfunctioning structures in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier antiglycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging.1-5<BR><BR>The new Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients:<BR><BR>Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines.6-11<BR><BR>Glucose and Free Radicals<BR><BR>Benfotiamine blocks multiple destructive biochemical pathways, including advanced glycation end-products’ (AGEs) formation pathway, which are induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal.12-14 Benfotiamine can correct endothelial cell defects induced by high glucose. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage.15<BR><BR>Aging results in protein glycation and the formation of AGEs in tissues throughout our body. Pyridoxamine, a form of vitamin B6, is an efficient AGE inhibitor — or cross-link breaker — that has been validated to protect the body’s aging proteins against carbonyl stress via multiple independent mechanisms.16-17<BR><BR>Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. A new microencapsulated Bio-Enhanced™ R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent.18-21 <BR><BR>The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. Acetyl-L-carnitine arginate is a patented form of carnitine that also stimulates the growth of neurites in the brain.<BR><BR>Supplement Facts<BR><BR>Serving Size 4 capsules<BR>Servings Per Container 30<BR>Amount Per Serving<BR><BR>Vitamin B6 (as pyridoxamine from pyridoxamine dihydrochloride) 50 mg<BR>Sodium 25 mg<BR>Carnosine 1000 mg<BR>Acetyl-L-carnitine arginate dihydrochloride 750 mg<BR>Benfotiamine 150 mg<BR>R-Lipoic Acid (as microencapsulated Bio-Enhanced™ stabilized Na-RALA® sodium R-lipoate) 150 mg<BR>Luteolin (high purity luteolin as Pureolin™) 8 mg<BR><BR>Other ingredients: magnesium stearate, gelatin, silicon dioxide.<BR><BR>Contains soybeans. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.<BR><BR>Bio-Enhanced™ is a trademark and Na-RALA® is a registered trademark of Geronova Research, Inc. <BR>Pureolin™ is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide.<BR><BR>Dosage and Use<BR> <BR>Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.<BR><BR>This product can be taken with or without food.<BR> <BR>Warnings:<BR>Keep out of reach of children.<BR>Do not exceed recommended dose.<BR>Do not purchase if outer seal is broken or damaged.<BR>If you have a bad reaction to product discontinue use immediately.<BR>When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.<BR><BR>www.lef.org Reprinted with permission of Life Extension.<BR><BR>References:<BR>1. Hormones (Athens). 2008 Apr-Jun;7(2):123-32.<BR>2. Protein Pept Lett. 2008;15(4):385-91.<BR>3. J Alzheimers Dis. 2007 May;11(2):229-40.<BR>4. Ann N Y Acad Sci. 2006 May;1067:369-74.<BR>5. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.<BR>6. Life Sci. 2007 Nov 30;81(23-24):1602-14.<BR>7. J Nutr. 2006 Jun;136(6):1517-21.<BR>8. Biochem Pharmacol. 2005 Jan 15;69(2):241-8.<BR>9. Immunology. 2005 Jul;115(3):375-87.<BR>10. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.<BR>11. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.<BR>12. Nat Med. 2003 Mar;9(3):294-9.<BR>13. Acta Diabetol. 2001;38(3):135-8.<BR>14. Diabetes. 2006 Aug;55(8):2231-7.<BR>15. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7<BR>16. Ophthalmic Res. 2006;38(5):294-302.<BR>17. Nephrol Dial Transplant. 2008 Feb;23(2):518-24.<BR>18. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9.<BR>19. FASEB J. 1999 Feb;13(2):411-8.<BR>20. Antioxid Redox Signal. 2000 Fall;2(3):473-83.<BR>21. Biochem Mol Biol Int. 1995 Oct;37(2):361-70.</P>
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<LI>SKU: 1268
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